IIT Indore researchers have studied how the cancer-causing virus affects brain cells and causes neurological problems.
Epstein-Barr virus (EBV) damage to brain cells has been discovered by researchers at the Indian Institute of Technology (IIT) Indore, and this damage may result in neurological diseases.
The Epstein Barr Virus (EBV), one of the most often detected viruses, is a member of the herpes virus family and is most frequently transmitted through bodily fluids, particularly saliva. Even though it normally has no negative effects, the virus might reactivate inside the body under specific peculiar circumstances, such as immunological stress or immunocompetence.
The research team from IIT Indore investigated the potential effects of a cancer-causing virus on brain cells using the Raman micro-spectroscopy technique and discovered that it causes a variety of changes in biomolecules such as fatty acids, carbohydrates, and protein components, leading to diseases of the central nervous system as well as brain cancer.
Scientists still don’t fully comprehend how this virus impacts and controls brain cells, though.
The research, which was published in the journal ACS Chemical Neuroscience, demonstrated that under the influence of viruses, numerous biomolecules in neuronal cells may undergo prompt and gradual alterations.
Dr. Hem Chandra Jha, group leader from the Infection Bioengineering group at IIT Indore, said in a statement that the research work “aids in the understanding of EBV-mediated biomolecular changes in the various compartments of the central nervous system leading to a better understanding of nervous system diseases.”
The scientists noticed that the viral effect caused the lipid, cholesterol, proline, and glucose molecules in the cells to rise. These biomolecular components might ultimately be crucial in the viral invasion of cells.
They also gained insight into whether these biomolecular alterations can be connected to the effects of viruses and neurological problems.
The work, the team continued, also contributes to demonstrating the benefits of Raman micro-spectroscopy, a low-cost and non-invasive method, in conducting research on virus-associated cellular problems in clinical settings. Compared to other approaches, which necessitate sophisticated settings for examining the virus-associated alterations in cells, tissues, and organs, it may offer an advantage in the analysis of clinical samples.
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